1、靶向蛋白动态构象变化的药物设计
2、肿瘤免疫系统的靶向调控
3、核酸免疫的化学调控

1、国家自然科学基金面上项目 2025.01-2028.12、49 万元、在研、主持
2、江苏省优秀青年基金2024-09 至 2027-08，50万元，在研，主持
3、国家自然科学基金面上项目 2023.01-2026.12、52 万元、在研、主持。
4、国家自然科学基金面上项目 2021.01-2024.12、56万元、在研、主持。

[1]Zi-Wen Feng, Ting Zeng, Qing Shu, Xiao-Zhong Li, Hai-Guo Yu, Wei Dai, Xue-Chun Liu, Xin-Jian Tian, Feng Xu, Hui Li, Ye-Ling Zhou, Shi-Duo Zhang, Lin-Lin Li, Nan-Nan Chen, Xiao-Yan Liu, Zi-Wen Liu, Jie Yin, Hong-Tao Shen, Chun-Chen Che, Mei-Rong Chen, Dan-Dan Wang, Ling-Yun Sun*, Yi-Bei Xiao*, Qi-Dong You* & Xiao-Li Xu*.A molecular glue induces aberrant STING oligomerization and inhibits autoinflammatory diseases. Signal Transduction and Targeted Therapy,11: 308, 2026.(IF: 81.2)
[2]Hui Li; Wei Zheng; Wenjing Bian; Mei Li; Zhidan Fan; Ziwen Feng; Xiaoyan Liu; Shiduo Zhang; Haohao Lu; Yinquan Huang; Jiaqing Jia; Yifan Zhang; Linlin Li; Chunchen Che; Haiguo Yu*; Yibei Xiao*; Qidong You*; Xiaoli Xu*; Rational Design of Carbazole-Based STING Inhibitors for Treating cGAS-STING Pathway-Driven Inflammatory Disorders, Nature Communications, 17: 7066, 2026.(IF: 18.1)
[3]Zi-Wen Feng; Li Li; Shi-Duo Zhang; Ying-Ji Wang; Jia-Yue Pei; Nan-Nan Chen; Bei-Duo Wu; Qiu-Ling Zheng; Qi-Dong You*; Xiao-Ke Guo*; Xiao-Li Xu*; Structural Optimization of Pyrazole Compounds as Hsp90 Regulators with Enhanced Antitumor Activity, Journal of Medicinal Chemistry, 68(10): 9886-9905, 2025,(IF: 7.3)
[4]Nan-Nan Chen, Qiang-Sheng Zhu, Wen-Jing Bian, Lin-Lin Li, Chen Tong, Guo-Feng Xin, Zi-Wen Feng, Shi-Duo Zhang, De-Chang Li, Chen-Yu Wang, Jia-Xi Han, Qi-Dong You*, Xiao-Li Xu*Discovery of tricyclic analogues as novel stimulator of interferon genes (STING) receptor agonists via structural optimization of a repurposed drug.Chinese Chemical Letters. In press 2026.(IF: 9.5)
[5]Nan-Nan Chen, Han Zhang, Qiang-Sheng Zhu, Ting Zeng, Wei Dai, Ye-Ling Zhou, Guo-Feng Xin, Bei-Duo Wu, Si-Jia Gong, Zheng-Yu Jiang*, Qi-Dong You*, and Xiao-Li Xu*. Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor. J. Med. Chem. 2023, 66, 8, 5584–5610. (IF: 7.3)
[6] Hui Li, Sheng-Lie Zhang, Yan-Han Jia, Qian Li, Zi-Wen Feng, Shi-Duo Zhang, Wei Zheng, Ye-Ling Zhou, Lin-Lin Li, Xue-Chun Liu, Ya-Qiong Chen, Hui Peng*, Qi-Dong You*, and Xiao-Li Xu* Imidazo[1,2-a]Pyridine Derivatives as Novel Dual-Target Inhibitors of ABCB1 and ABCG2 for Reversing Multidrug Resistance. J. Med. Chem. 2023, 66, 2804−2831.(IF: 7.3)
[7]. Qiangsheng Zhu, Nannan Chen, Xinjian Tian, Yeling Zhou, QiDong You*, and Xiaoli Xu* Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective. J. Med. Chem. 2022, 65, 12, 8065–8090.(IF: 7.3)
[8]. Li Li, Nannan Chen, Dandan Xia, Shicheng Xu, Wei Dai, Yuanyuan Tong, Lei Wang, Zhengyu Jiang*, Qidong You*, Xiaoli Xu*.  Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification. Cell Chemical Biology. 2021.28（10), 1446-1459.e6.(IF: 9.0)